Ontological Unlocking: The Mystical Practices of Eastern Orthodoxy with Vladimir Miskovic

New Thinking Allowed with Jeffrey Mishlove May 24, 2026 Vladimir Miskovic was formerly Assistant Professor of Psychology and Integrative Neuroscience at Binghamton University (SUNY) and a research scientist at X: The Moonshot Factory, previously known as Google X. He is also a former novice monk. He is coauthor with Stephen Jay Lynn of Dreaming Reality: How Neuroscience and Mysticism Can Unlock the Secrets of Consciousness. Vladimir explores Hesychasm, the mystical contemplative tradition of Eastern Orthodoxy centered on interior stillness, the Jesus Prayer, and the transformative process known as theosis. Drawing from both neuroscience and monastic experience, he discusses how practices such as nepsis (watchfulness) may reshape consciousness, regulate the default mode network, and cultivate deeper states of compassion, awareness, and spiritual embodiment. Miskovic also examines parallels between Eastern Orthodox mysticism, Sufism, Buddhism, Kabbalah, and other contemplative traditions while preserving the unique theological vision of Christian mystical life. 00:00:00 Introduction 00:06:15 Hesychasm and interior stillness 00:13:02 Image and likeness of God 00:16:41 Transformation and theosis 00:23:11 Nepsis and watchfulness 00:27:21 Default mode network and mystical practice 00:37:29 Jesus prayer and prayer of the heart 00:45:19 Neuroscience and transformed consciousness 00:46:31 Sufism and comparative mysticism 01:01:02 Conclusion (Recorded on Friday, May 1, 2026)

Telomerase

  • Google AI Overview

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Telomerase is a specialized enzyme that adds repetitive DNA sequences to the ends of chromosomes (telomeres). By rebuilding these protective chromosome “caps,” it prevents telomeres from degrading during cell division, effectively allowing cells to bypass aging limits and divide indefinitely. [1, 2, 3, 4]

Core Function & Mechanism

  • What it is: A ribonucleoprotein (a complex of protein and RNA) that acts as a reverse transcriptase.
  • How it works: It carries its own RNA template, which it uses to bind to the ends of chromosomes and synthesize new telomeric DNA.
  • The “end-replication problem”: During normal cell division, DNA polymerase cannot copy the very ends of linear chromosomes. This causes telomeres to naturally shorten with every cycle. Telomerase counters this by actively extending the chromosome ends. [1, 2, 3, 4, 5]

Role in the Body

  • Stem Cells & Germ Cells: Telomerase is highly active in embryonic stem cells, adult stem cells, and sperm/egg cells. This allows these cells to continuously divide and maintain tissue regeneration without losing vital genetic data.
  • Normal Somatic Cells: In most of your regular body cells, telomerase is largely inactive. As these cells divide, their telomeres get progressively shorter until they reach a critical threshold. At this point, the cells stop dividing (senescence) or die, which contributes to the biological aging process. [1, 2, 3, 4, 5]

Implications in Health & Disease

  • Cancer: Most normal cells have strict limits on how many times they can divide. However, over 90% of cancer cells abnormally reactivate telomerase. This endless replenishment of telomeres gives cancer cells their signature “immortality” and allows them to proliferate uncontrollably.
  • Aging & Therapy: Because low telomerase activity leads to shorter telomeres and cellular aging, researchers are investigating it as a target for both anti-aging therapies (stimulating telomerase) and cancer treatments (inhibiting telomerase). [1, 2, 3, 4, 5]

To dive deeper into the biology, cellular aging, and targeted therapies, consult the authoritative National Cancer Institute definition or explore reviews on telomere and telomerase research via PubMed Central.

Shit

From Wikipedia, the free encyclopedia

This article is about the word. For the bodily waste, see Feces. For the expulsion of feces, see Defecation. For other uses, see Shit (disambiguation).

“S***” and “S**t” redirect here. For the derogatory term, see Slut.

Shit is an English-language profanity. As a noun, it refers to fecal matter, and as a verb it means to defecate; in the plural (“the shits”), it means diarrheaShite is a common variant in British and Irish English.[1] As a slang term, shit has many meanings, including: nonsense, foolishness, something of little value or quality, trivial and usually boastful or inaccurate talk or a contemptible person. It could also be used to refer to any other noun in general or as an expression of annoyance, concern, surprise or anger.

Etymology

The word is likely derived from Old English, having the nouns scite (dung, attested only in place names) and scitte (diarrhoea) and the verb scītan (to defecate, attested only in bescītan, to cover with excrement); eventually it morphed into Middle English schītte (excrement), schyt (diarrhoea) and shiten (to defecate), and it is virtually certain that it was used in some form by preliterate Germanic tribes at the time of the Roman Empire. The word may be further traced to Proto-Germanic *skit-, and ultimately to Proto-Indo-European *skheid– “cut, separate”, the same root believed to have become the word shed. The word has several cognates in modern Germanic languages, such as German ScheißeDutch schijtSwedish skitIcelandic skíturNorwegian skitt etc. Ancient Greek had ‘skōr’ (gen. ‘skatos’ hence ‘scato-‘), from Proto-Indo-European *sker-, which is likely unrelated.[2]

Usage

“Piece of shit” redirects here. For other uses, see Piece of shit (disambiguation).

The word shit (also shite in British and Hiberno-English[3]) is considered profanity and is usually avoided in formal speech. Minced oath substitutes for the word shit in English include shoot,[4][5] shucks,[6] sugar,[7] and the euphemistic backronymSugar, Honey, Ice(d) Tea.[8][9]

In the word’s literal sense, it has a rather small range of common usages. An unspecified or collective occurrence of feces is generally shit or some shit; a single deposit of feces is sometimes a shit or a piece of shit; and to defecate is to shit or to take a shit. While it is common to speak of shit as existing in a pilea loada hunk, and other quantities and configurations, such expressions flourish most strongly in the figurative.

When uttered as an exclamation or interjectionshit may convey astonishment or a feeling of being favorably impressed or disgusted. Similar utterances might be damn!wow! or yuck!.

Piece of shit may also be used figuratively to describe a particularly loathsome individual, or an object that is of poor quality (“this car is a piece of shit“, often abbreviated to “P.O.S.”).

One study published in 2017 argued that “shit studies” is a cross-disciplinary meta-field of rhetorical inquiry about human communication and reasoning. The authors explained, “rhetorical studies has theorized ‘shit’ in terms of the communication of transformation, style, and textual relations,” particularly in relation to claims of expertise to topics such as “anti-semitism” and “wine-tasting.”[10] They conclude that bullshit speech is one-sided discourse that is difficult to penetrate because it contains “ideological barriers to the expectation of mutuality,” working to deflect critical responses.

Vague noun

Shit can be used as a generic mass noun similar to stuff; for instance, This show is funny (as) shit or This test is hard (as) shit, or That was stupid shit. These three usages (with funnyhard, and stupid or another synonym of stupid) are heard most commonly in the United States. Using “as” denotes a subtle change in the meaning of the expression; however, the overall intent is basically the same.

In the expression Get your shit together!, the word shit can refer either to one’s wits or composure or to one’s things, gear, etc. He doesn’t have his shit together means that his affairs are disordered, reflecting not bad luck or forces beyond his control, but his personal shortcomings.

To shoot the shit is to have a friendly but pointless conversation, as in “Come by my place some time and we’ll shoot the shit.”

shithole is any unpleasant place to be, much like a hellhole. This usage originates from a reference to a pit toilet.

crock of shit is something (a situation, explanation, argument, etc.) that is nonsense or fabricated as a deception or evasion; i.e. bullshit. Often abbreviated simply as crock. Example: “You expect me to believe that ?? What a crock!”

The phrase built like a brick shithouse is used in the United States to compliment a curvaceous woman, but in other English-speaking countries to compliment men with athletic physiques.[11] This meaning originates from the observation that most shithouses are rather ramshackle affairs constructed of plywood or scrap sheets of steel.

The shitter is a slang term for a toilet, and can be used like the phrase … down the toilet to suggest that something has been wasted. Example: “This CD player quit working one friggin’ week after I bought it, and I lost the receipt! Twenty bucks right down the shitter!”

Shit on a shingle is U.S. military slang for creamed chipped beef on toast. In polite company, this can be abbreviated as SOS.[12][13]

Trouble

Shit can be used to denote trouble, by saying one is in a lot of shit or deep shit (a common euphemism is deep doo-doo). A shitstorm would be quite a lot of trouble happening all in one place at one time. It’s common for someone to refer to an unpleasant thing as hard shit (You got a speeding ticket? Man, that’s some hard shit), but the phrase tough shit is used as an unsympathetic way of saying too bad to whoever is having problems (You got arrested? Tough shit, man!) or as a way of expressing to someone that they need to stop complaining about something and cope with it instead (Billy: I got arrested because of you! Tommy: Tough shit, dude, you knew you might get arrested when you chose to come with me.) Note that in this case, as in many cases with the term, tough shit is often said as a way of pointing out someone’s fault in his/her own current problem. It’s also common to express annoyance by simply saying Shit.

shitload of something is a large quantity, especially something unpleasant or disgusting. The boss dumped a shitload of extra work for me this week. A shit sandwich is something (like a situation or state of affairs) unpleasant made triflingly more palatable by packaging it in things less unpleasant, as rotten meat sandwiched in bread. The term shit sandwich originates from an old joke that goes: “Life is a shit sandwich. The more bread (money) you got, the less shit you have to eat.”

Up shit creek or especially Up shit creek without a paddle describes a situation in which one is in severe difficulties with no apparent means of solution (this is simply a profane version of the older saying “up the creek without a paddle”, profanity added for emphasis or humor).

Shit happens means that bad happenings in life are inevitable. This is usually spoken with a sigh or a shrug, but can be spoken derisively to someone who complains too often about his ill fortunes, or in an irritating manner.

When the shit hits the fan is usually used to refer to a specific time of confrontation or trouble, which requires decisive action. This is often used in reference to combat situations and the action scenes in movies, but can also be used for everyday instances that one might be apprehensive about. I don’t want to be here when the shit hits the fan! indicates that the speaker is dreading this moment (which can be anything from an enemy attack to confronting an angry parent or friend). In polite society, it is often reduced to “when it hits the fan”. He’s the one to turn to when the shit hits the fan is an indication that the person being talked about is dependable and will not run from trouble or abandon their allies in tough situations. The concept of this phrase is simple enough, as the actual substance striking the rotating blades of a fan would cause a messy and unpleasant situation (much like being in the presence of a manure spreader). Whether or not this has actually happened, or if the concept is simply feasible enough for most people to imagine the result without needing it to be demonstrated, is unknown. Another example might be the saying shit rolls downhill, a metaphor suggesting that trouble for a manager may be transferred to the subordinates. There are a number of anecdotes and jokes about such situations, as the imagery of these situations is considered to be funny. This is generally tied-in with the concept that disgusting and messy substances spilled onto someone else are humorous.

For someone to be described as shitfaced means that person is essentially incapacitated by alcoholic intoxication (i.e. in a thoroughly drunken state).

Displeasure

Shit can comfortably stand in for the terms bad and anything in many instances (Dinner was good, but the movie was shit. You’re all mad at me, but I didn’t do shit!). A comparison can also be used, as in Those pants look like shit, or This stuff tastes like shit. Many usages are idiomaticI’m shit out of luck usually refers to someone who is at the end of their wits or who has no remaining viable options. In polite company the acronym SOL is commonly substituted for this. That little shit shot me in the ass, suggests a mischievous or contemptuous person. Euphemisms such as crap are not usually used in this context.

The exclamations oh shit! and aw shit! are used to express displeasure or embarrassment (sometimes facetiously) with oneself when one makes a mistake, especially a stupid or avoidable mistake. When used to comment on the actions of someone else, they can take on a more humorous quality if the mistake does not result in serious consequences. Oh shit! is also a reflexive expression of horror or terror, as when witnessing or being involved in a life-threatening situation (for example, a vehicle accident).

The term piece of shit is generally used to classify a product or service as being sufficiently below the writer’s understanding of generally accepted quality standards to be of negligible and perhaps even negative value. The term piece of shit has greater precision than shit or shitty in that piece of shit identifies the low quality of a specific component or output of a process without applying a derogatory slant to the entire process. For example, if one said “The youth orchestra has been a remarkably successful initiative. The fact that the orchestra’s recent rendition of Tchaikovsky’s Manfred Symphony in B minor was pretty much a piece of shit should not in any way detract from this.” The substitution of shit or shitty for pretty much a piece of shit would imply irony and would therefore undermine the strength of the statement.

The phrase “(I don’t) give a shit” can be used when one does not care about something, or has a passive attitude toward said thing, as it denotes indifference. In context, one can say: “You’re offended? Well, I don’t give a shit!” or “You’re telling me? Go find somebody who gives a shit.” President Richard Nixon said to aide H.R. Haldeman while being tape recorded in the Oval Office, “I don’t give a shit about the lira.” He meant he was too busy managing the Watergate affair to consider a crisis in the Italian monetary system.[14]

The shit list is a category of people who are in ill favor with some individual or group of people, perhaps as the managers of a company, and likely to be the targets of special treatment.

The phrase “take shit” means to receive bad or frivolous treatment from someone. Such an abused person might say “I’m not taking any more of your shit!” to indicate that they will no longer tolerate such treatment.

Whale shit[citation needed] is sometimes used to describe a person who inspires displeasure or disgust, as in: “You’re lower than whale shit at the bottom of the ocean!”

“You can’t polish shit” is a popular aphorism roughly equivalent to “putting Lipstick on a pig” (although “a turd” is more commonly used). However, the TV show Mythbusters showed that a person can, in fact, polish a turd.

Continue reading Shit

Confucius on originality

Depiction of Confucius by Wu Daozi, 8th century CE

“I am not an originator but a transmitter.”

~ Confucius

Confucius, born Kong Qiu, was a Chinese philosopher of the Spring and Autumn period who is traditionally considered the paragon of Chinese sages. Much of the shared cultural heritage of the Sinosphere originates in the philosophy and teachings of Confucius. Wikipedia

BornKong Qiu
c. 551 BCE
Zou, Lu (now QufuShandong)
Diedc. 479 BCE (aged 71–72)
Si River, Lu

New breakthrough brings researchers closer to a “functional cure” for HIV

Three people were able to suppress the virus for months without their usual treatment regimen.

Photo of the author

Greg Owen May 16, 2026 (LGBTQNation.com)


A 3D medical illustration showing an HIV retrovirus targeting T-cells.A 3D medical illustration showing an HIV retrovirus targeting T-cells. | Shutterstock

An HIV expert at the University of California, San Francisco, presented evidence this week of a major advance in the search for a “functional cure” for HIV infection

“It is inspiration and a potential road map to get to where we need to go,” said Dr. Steve Deeks, who leads a team of researchers at Caring Cross, a nonprofit focused on developing broadly available immunotherapies.


Related

A cure for HIV is in sight. Here’s what scientists are working on.


Deeks presented the group’s findings at a gene therapy conference in Boston on Tuesday.

After a single infusion of immune cells engineered to recognize HIV, the virus in two study participants was suppressed to undetectable levels. Suppression has lasted nearly two years for one of the patients, The New York Times reports.

Based on technology already developed to attack cancer cells, the scientists at Caring Cross engineered immune cells from each study participant to carry two molecules on the immune cells’ surface. Both bind to HIV and kill infected cells, but one also prevents the immune cells from becoming infected.

“It’s this dual nature of targeting — killing and protecting — that we think is the missing piece in terms of how this therapy works,” Dr. Boro Dropulić, executive director of Caring Cross, told The Times.

After extracting and modifying each patient’s immune cells, researchers injected them back in, in a process called infusion.

HIV positive individuals who stop taking antiretroviral drugs (ARVs) will typically see the virus roar back within two weeks. But two of the study participants have remained undetectable after 92 and 48 weeks, respectively, after infusion and simultaneously stopping antiretroviral therapy.

A third participant partially suppressed the virus for 12 weeks before rebounding.

All three participants had started antiretroviral therapy shortly after infection, a key finding versus others in the study who lived longer with HIV before taking ARVs, and who didn’t respond as well to the modified immune cell therapy.

Researchers say that might be because HIV hides deep in the body where it evades both the immune system and drugs designed to track it down; the longer an individual harbors HIV without the suppressing effects of ARV therapy, the longer it has a chance to replicate and build up in those deep recesses.

“Three out of three people with early disease doing some degree of control, to me, is the most provocative finding here,” Dr. Deeks said.

“This work represents the culmination of years of scientific and clinical effort to develop a therapy that harnesses the body’s own immune cells to fight HIV,” Dr. Dropulić said in a statement from the group. He called it an important step toward “a definitive therapeutic solution.”

“We have already advanced next-generation versions that we expect will further enhance the potency and durability of the anti-HIV response, bringing us closer to a lasting, potentially one-time treatment.”   

Scientists envision a single shot that one day will keep HIV at undetectable levels for a lifetime, a “functional cure” that takes into account HIV’s still unexplained ability to linger deep in the body, however healthy an individual may be.

Remarkable strides in treatment have already been made over the last several years, keeping the virus at bay with ARVs in daily pill form and monthly or bi-monthly injections, along with longer-acting options in the pipeline, including weekly and monthly pills, and shots that could be given just once a year.

On the prevention side, use of PrEP has grown to more than 3.5 million people worldwide, according to the National Institutes of Health.

An affordable “one-time treatment” for the virus would all but spell the end of the HIV epidemic, eliminating the potential interruptions in sustained treatment for at-risk populations seen in the current administration’s dismantling of PEPFAR worldwide, and the loss of health insurance coverage and access from Medicaid cuts in the U.S.

Caring Cross estimates 1.3 million new HIV infections occur each year, more than 700,000 people die annually from HIV-related causes, and more than 40 million people are living with HIV worldwide.

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Greg Owen writes about politics and culture for LGBTQ Nation. An award-winning writer, producer and journalist, he was recently recognized for Excellence in Online Journalism by NLGJA: the Association of LGBTQ Journalists for his coverage of the 2024 election. He’s written for Q Digital since 2015 and for LGBTQ Nation since 2022.

Death Cafe

From Wikipedia, the free encyclopedia

Named afterBernard Crettaz’s “café mortel”
Formation2011
FounderJon Underwood
Legal statusNon-profit
PurposeDeath
Websitehttps://deathcafe.com/

Death Cafe is a scheduled non-profit get-together (called “social franchises” by the organisers) for the purpose of talking about death over food and drink, usually tea and cake. The idea originates with the Swiss sociologist and anthropologist Bernard Crettaz, who organized the first café mortel in 2004.[1] Jon Underwood, a UK web developer, was inspired by Crettaz’s work, introduced the death cafe to London in 2011, and launched the Death Cafe website.[2] They have since been held in many countries.

Format and purpose

Death Cafes are events, usually lasting two hours with around a dozen participants, were people discuss their understanding, thoughts, dreams, fears and any other aspects of death and dying over tea and cake.There is no fixed venue, and the events have previously been held in homes, rented halls, restaurants, cafes[3][4][5][6], a cemetery[7] and a yurt.[8] Some Death Cafes have specifically created an opportunity for health-care professionals to talk about death.[9]

The Death Cafe website states the purpose is “to increase awareness of death with a view to helping people make the most of their (finite) lives”.[10] The open-ended discussions also provide an avenue to express thoughts about one’s own life stirred up by the death of a family member.[9]

Crettaz said that his aim of his café mortel was to break the “tyrannical secrecy” surrounding the topic of death,[3] and that at these gatherings, “the assembled company, for a moment, and thanks to death, is born into authenticity.”[11] This is echoed by Underwood, who stated that “we have lost control of one of the most significant events we ever have to face”,[8] and facilitators who have said that there is “a need among people to open [the] closet”[4] into which death, the “last taboo”, has been placed, to reduce fear and enable people to live more fully.[3][4]

History

Crettaz organized the first café mortel in 2004 in Neuchâtel,[3][12] and in 2010 brought the idea to Paris.[citation needed] He published a book titled Cafés Mortels: Sortir la Mort du Silence (Death Cafes: Bringing Death out of Silence).[13] According to one commentator, Crettaz wanted to revive the pagan tradition of the funeral feast, “where the living would renew their bonds while letting go of what weighed on their hearts”.[14]

In 2011, inspired by Crettaz and with his guidance, Underwood held the first London Death Cafe at his home in Hackney.[3][10] He subsequently developed the Death Cafe website, generating guidelines with his mother, psychotherapist Susan Barsky Reid, and the concept was taken up globally.[4][15][16] The first US event was organized by Lizzy Miles, a hospice worker, in summer 2012 near Columbus, Ohio.[17][18][19] By June 2014, the idea had spread to Hong Kong,[20] and it was subsequently popularized in Shanghai by a non-profit organization that provides hospice services to cancer patients.[21] Café Totentanz or Totentanz-Café is used in German-speaking areas.[12][22]

In February 2013, a Death Cafe in London was filmed.[23]

Underwood died in June 2017; Death Cafe has since been run by his mother Susan Barsky Reid, his sister Jools Barsky, and his wife Donna Molloy.[24][10]

After hosting a Death Café in Perth, Scotland, counsellor and social entrepreneur Rachel Weiss was inspired to use the model for talking about menopause.[citation needed] Weiss hosted the first Menopause Café in 2017 in Perth and there are now cafés across the world.[25]

More at: https://en.wikipedia.org/wiki/Death_Cafe

“What then is the American, this new man?”

“What then is the American, this new man? He is neither an European, nor the descendant of an European…He is an American. Here individuals of all nations are melted into a new race of men, whose labours and posterity will one day cause great changes in the world…. The American ought therefore to love his country much better than that wherein either he or his forefathers were born.”
― J. Hector St. John de Crèvecoeur

Key Characteristics of this “New Man” from Google AI:

Crèvecœur outlined several fundamental traits that defined this emerging American identity: [1, 2, 3]

  • The Melting Pot: Crèvecœur observed that Americans were a “strange mixture of blood”, combining English, Scottish, Irish, French, Dutch, and German heritages—a blend found nowhere else in the world.
  • Upward Mobility and Self-Reliance: Unlike the rigid social classes of Europe, where a few possessed everything and the majority had nothing, the American was free from oppressive lords and despotic princes. They were independent, hard-working, and rewarded directly for their own labor.
  • Driven by Self-Interest: The new American was motivated by a desire to improve their life and provide for their family, thriving in a land that offered them land, bread, and protection.
  • Adaptability: This new man easily embraced new modes of life and obeyed a new government, willingly shedding old world traditions in favor of embracing new ones. [1, 2, 3, 4]

You can read the original text in Letter III of Letters from an American Farmer to explore this historical vision of the American character in depth. [1]

Michel Guillaume Jean de Crèvecœur, naturalized in New York as John Hector St. John, was a French-American writer, diplomat, and farmer. Wikipedia

Born January 31, 1735, Caen, France

Died November 12, 1813 (age 78 years), Sarcelles, France

Rage and the Republic: The Unfinished Story of the American Revolution | Jonathan Turley

Socrates in the City May 22, 2026 2 products Socrates in the City earns commission on tagged products. Why do most revolutions collapse into chaos, tyranny, or bloodshed, while the American Revolution produced one of the most enduring republics in history? In this episode of The Revolution, Socrates in the City’s newest program, host Eric Metaxas is joined by American author and legal scholar, Jonathan Turley to discuss his book, Rage and the Republic: The Unfinished Story of the American Revolution. They use Thomas Paine’s journey as the lens through which to explore that question. A man who stood at the center of both the American and French Revolutions, Paine embodied the brilliance and danger of revolutionary fervor itself: visionary yet reckless, prophetic yet deeply flawed. Alongside his unlikely friendship with Benjamin Franklin, this conversation examines why America succeeded where so many revolutions failed, the tension between liberty and rage, and the enduring invitation of the American experiment today. Get Professor Turley’s new book “Rage and the Republic: The Unfinished Story of the American Revolution” https://a.co/d/0a3A8quu

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